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Meniran Plant Herbal Benefits

 

There are several types of meniran, but the ones better known to the general public and commonly used for treatment are only two species, namely Phyllanthus niruri, L., and Phyllanthus urinaria, L. Both have almost the same morphology and efficacy for treatment.

Ethnophytomedically, quoted from usu.ac.id, meniran has long been used by people in various parts of the world. In Indonesia, which is rich in tropical forest flora, meniran singly or mixed with other medicinal plants are traditionally used to treat various diseases, such as diarrhea, malaria, thrush, kidney stones, jaundice, epilepsy, toothache, gonorrhea, and anti-inflammatory. (Kardinan and Kusuma, 2004).

In Vietnam and Cambodia, meniran is used to ward off tuberculosis. In Thailand, this herb is traditionally used to ward off fever and laxative urine. In Malaysia, meniran is used to prevent skin diseases, syphilis, and gonorrhea.

Meanwhile, in India, based on Ayurvedic medicine, since 2,000 years ago, meniran has been widely used to treat menstrual disorders, diarrhea, skin disorders, diabetes, gonorrhea, and can overcome hepatitis B.

In Peru, meniran mixed with lime juice, drunk as a tonic for people with diabetes mellitus and hepatitis sufferers. In Suriname, meniran is used to ward off colic, kidney disorders, and various acute or chronic liver diseases.

Meniran plants, according to Wikipedia, have chemical compounds such as philanthine, potassium, resin, and tanning substances. This plant can be used to cure jaundice, dysentery, cough, fever, epilepsy, excessive menstruation, and malaria. Meniran, quoted from unsrat.ac.id, also contains antifungal compounds such as flavonoids, tannins, and saponins.

The research team from the Pharmacology and Therapeutics Section of the Faculty of Medicine, Sam Ratulangi University, Manado, tested the antipyretic effect of meniran extract on male Wistar rats induced by the DPT HB vaccine. Induction of fever in test animals was carried out using 0.2ml DPT-HB vaccine intramuscularly.

The results showed that administration of meniran extract at a dose of 300 mg/200 g BW showed a more significant decrease in rectal temperature than doses of 100 and 200 mg/200 g BW for 180 minutes of measurement. The results showed that meniran extract had an antipyretic effect on Wistar rats.

The research team from the Dentistry Education Study Program, Faculty of Medicine, Sam Ratulangi University, examined the inhibition test of meniran extract on the growth of Candida albicans isolated from acrylic removable denture plates.

Candida albicans is a normal flora in the mouth, but Candida albicans acrylic denture users can overgrow if not kept clean. The overgrowth of Candida albicans fungus can cause infection in the oral cavity of acrylic denture wearers.

Meniran is an alternative to overcome the fungus Candida albicans. The conclusion of their study stated that meniran extract could inhibit the growth of the fungus Candida albicans isolated from acrylic removable denture wearers.

The research team of the Postgraduate Program in Anti-Aging Medicine, Department of Pharmacology, Faculty of Medicine, Udayana University, Denpasar, examined the meniran leaf extract gel to increase the epithelialization of wound healing in the skin of white male rats of Wistar strain. Meniran leaves contain bioactive molecules that have an effect on wound healing and are antimicrobial. The results showed that the administration of meniran leaf extract gel could increase the epithelialization of wound tissue on the skin of male Wistar rats.

The research team of UGM students, quoted from ugm.ac.id, examined immer and meniran, which are known to treat inflammation or swelling. Imer leaves contain high levels of securinine compounds that can reduce inflammation. While meniran leaves contain phyllantin compounds and are proven to have the anti-inflammatory activity to strengthen immunity.

The research was conducted by extracting the two leaves. Furthermore, the extract was tested on rats previously induced with inflammatory compounds in the legs. In addition to conducting in vivo tests on mice, in a study conducted in January-August 2016, an in silico test was also shown to determine the mechanism of immer and meniran leaves inhibiting inflammation.

The results showed that securinine and philanthine compounds were able to inhibit the cox-2 enzyme that causes inflammation. Research related to meniran leaves and imer simultaneously for this inflammatory drug was first conducted worldwide. So far, new research has only been conducted on meniran or immers, not a combination of the two.

The anti-inflammatory drug Nutrasetikal Imer Meniran or Nu Imran is expected to be an alternative for the community in treating inflammation.

Research by Tita Bariah Siddiq from the Faculty of Medicine, Maranatha Christian University, Bandung, regarding the effect of meniran herbs as antihepatotoxic, said that the active substances contained in meniran which have the most substantial effect as antihepatotoxic are philanthine and hypophilanthine. Both compounds belong to the lignan group, which has a free hydrogen group. The free hydrogen works as an antioxidant, which will bind to free radicals contained in toxic substances that often cause liver damage.

Through this research, Tita Siddiq wanted to know whether meniran can be used as an alternative hepatotoxic treatment so that people can use this plant as an antihepatotoxic drug. The results showed that meniran has an antihepatotoxic effect, with its mechanism of action as an antioxidant.

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